Symbol
Name
ID

Grid2
glutamate receptor, ionotropic, delta 2
MGI:95813

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Oculomotor apraxia

Cerebellar vermis atrophy

Cerebellar atrophy

Ataxia

Dysdiadochokinesis

Dysmetria

Gait ataxia

Truncal ataxia

Incoordination

Babinski sign

Delayed speech and language development

Dysarthria

Intellectual disability

Hyperreflexia

Global developmental delay

Disease(s) Associated with GRID2

autosomal recessive spinocerebellar ataxia 18

Mouse Phenotypes

nervous system phenotype

abnormal neuron mitochondrial morphology

abnormal cerebellum development

abnormal cerebellar foliation

reduced cerebellar foliation

thin external granule cell layer

abnormal midbrain morphology

abnormal cochlear VIII nucleus morphology

abnormal trigeminal motor nucleus morphology

abnormal hindbrain morphology

abnormal cerebellum morphology

abnormal cerebellar cortex morphology

abnormal cerebellar Purkinje cell layer

abnormal Purkinje cell morphology

Purkinje cell degeneration

abnormal Purkinje cell dendrite morphology

decreased Purkinje cell number

abnormal cerebellar granule layer morphology

decreased cerebellar granule cell number

abnormal cerebellar molecular layer

thin cerebellar molecular layer

abnormal cerebellum lobule morphology

small cerebellum

cerebellum atrophy

abnormal Purkinje cell innervation

abnormal CNS synapse formation

abnormal synapse morphology

abnormal myelination

abnormal action potential

abnormal CNS synaptic transmission

abnormal GABA-mediated receptor currents

abnormal excitatory postsynaptic currents

prolonged excitatory postsynaptic current decay time

prolonged excitatory postsynaptic current rise time

increased miniature inhibitory postsynaptic current amplitude

increased prepulse inhibition

absent long-term depression

reduced long-term depression

abnormal synaptic neurotransmitter level

Availability

Mouse Genotype

Grid2^ho-4J/Grid2^ho-4J

Grid2^ho-cpr/Grid2^ho-cpr

Grid2^ho-Jwg/Grid2^ho-Jwg

Grid2^ho-Nancy/Grid2^ho-Nancy

Grid2^ho/Grid2^ho

Grid2^Lc/Grid2^Lc

Grid2^tm1(cre)Mwa/Grid2^tm1(cre)Mwa

Grid2^tm1Mim/Grid2^tm1Mim

Grid2^tm1Mmsh/Grid2^tm1Mmsh

Grid2^tm2Msmh/Grid2^tm2Msmh

Grid2^ts3/Grid2^ts3

Grid2^Lc-J/Grid2⁺

Grid2^Lc/Grid2⁺

Grid2^Lc/Grid2^ho-Nancy

Grid2^{tm1(cre/PGR*)Ksak}/Grid2^tm2Mim (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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